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The third time that an ACO's benchmark is adjusted based on the ACO's regional service area expenditures, CMS calculates the regional adjustment using the 50 percent of the difference between the average per capita amount of expenditures for the ACO's regional service area and the average per capita amount of the ACO's rebased historical benchmark if the ACO is determined to have lower spending than the ACO's regional service area ( 425.656(e)(3)(i))

Notably, these proteins have a close relationship with high-density lipoprotein particle, response to estrogen, response to estradiol, exopeptidase activity, and peptidase activity (Figure 2E, see also Supplementary Tables S4S6)

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